PP2 Prevents Isoproterenol Stimulation of Cardiac Pacemaker Activity

Erosive Pressure Dermatitis Associated with Cardiac Pacemaker

Erosive dermatitis is a skin reaction associated with implantable cardiac devices (ie, pacemakers and cardioverter defibrillators). We report a 65-year-old man with a history of several cerebrovascular attacks who developed an erythematous crusted erosive patch over the pacemaker site after implantation of two subsequent pacemakers. We suggest that physical irritation may be a trigger factor fo...

Gallic acid prevents isoproterenol-induced cardiac hypertrophy and fibrosis through regulation of JNK2 signaling and Smad3 binding activity

Gallic acid, a type of phenolic acid, has been shown to have beneficial effects in inflammation, vascular calcification, and metabolic diseases. The present study was aimed at determining the effect and regulatory mechanism of gallic acid in cardiac hypertrophy and fibrosis. Cardiac hypertrophy was induced by isoproterenol (ISP) in mice and primary neonatal cardiomyocytes. Gallic acid pretreatm...

Simvastatin prevents isoproterenol-induced cardiac hypertrophy through modulation of the JAK/STAT pathway

Simvastatin (SIM) is a lipid-soluble inhibitor of hydroxy-3-methylglutaryl coenzyme A reductase with multiple reported therapeutic benefits. The present study was designed to investigate the effect of pretreatment with SIM on isoproterenol (ISO)-induced cardiac hypertrophy in rats. Twenty-four male albino Wistar rats weighing 180-200 g were divided into four groups. Groups I and III received no...

The Functional Role of Chloride Channels in Cardiac Pacemaker Activity

Sexual dimorphism in the complexity of cardiac pacemaker activity.

This study explored the effects of gender and aging on the complexity of cardiac pacemaker activity. Electrocardiogram signals were studied in normal women (n = 240) and men (n = 240) ranging in age from 40 to 79 yr. Nonlinear analysis of short-term resting R-R intervals was performed using the correlation dimension (CD), approximate entropy (ApEn), and largest Lyapunov exponent (LLE). Evidence...